Headline : The First Sleep Apnea Drug Is Here

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The weight-loss drug Zepbound (tirzepatide) now has another major benefit: on Dec. 20, it became the first drug approved by the U.S. Food and Drug Administration (FDA) to treat obstructive sleep apnea.

In the trial that Lilly, the drug's manufacturer, submitted in April to the FDA, scientists reported that the drug helped people who were overweight or obese with sleep apnea reduce a standard measure of restricted breathing by 63%, leading to 30 fewer interrupted sleep events a night on average compared to those given a placebo. The study, which followed people for a year, included two analyses; one involved people who took only Zepbound and were compared to a placebo group, and another had people take Zepbound paired with a positive airway pressure (PAP) device, which is currently one of the standard treatments for obstructive sleep apnea. That group was compared to one taking a placebo and using PAP.

“This is the first pharmacologic therapy that can treat obstructive sleep apnea in this way,” says Dan Skovronsky, chief scientific officer at Eli Lilly.

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